Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 15, Issue 5, Pages 531-538Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2003.08.002
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- NCI NIH HHS [1P01CA71932] Funding Source: Medline
- NIGMS NIH HHS [GM 62116] Funding Source: Medline
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Leukocyte recruitment in acute and chronic inflammation is characterized by sequential cell adhesion and activation events. E-, P- and L-selectins mediate initial leukocyte-endothelial-cell adhesion events required for this process. Each selectin recognizes related but distinct counter-receptors displayed by leukocytes and/or the endothelium. These counter-receptors correspond to specific glycoproteins whose 'activity' is enabled by carefully controlled post-translational modifications. Characterization of the glycans associated with E- and beta-selectin counter-receptors, and of mice with targeted deletions of glycosyltransferase and sulfotransferase genes, disclose that neutrophil E- and/or beta-selectin counter-receptor activities derive, minimally, from essential synthetic collaborations amongst polypeptide N-acetylgalactosaminyltransferase(s), a beta-N-acetylglucosaminyltransferase that assembles core-2-type O-glycans, beta-1,4-galactosyltransferase(s), protein tyrosine sulfotransferase(s), alpha-2,3-sialyltransf erases, and a pair of alpha-1,3-fucosyltransferases.
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