Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 3, Issue 10-11, Pages 1557-1562Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-5769(03)00178-4
Keywords
lentinan immunomodulation; experimental tuberculosis
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Protective effects of Lentinan (Ajinomoto, Japan) against Mycobacterium tuberculosis infection were studied by in vitro and in vivo mouse models. The effectiveness of Lentinan administrated intraperitoneally (i.p.) before infection at a dose of 1 mg/kg three times at 2-day intervals was monitored in vivo by several parameters (body temperature; spleen weight; CFU counts of M. tuberculosis in spleen, liver and lung; and histomorphological observations). Peritoneal macrophages obtained from animals treated with Lentinan were greatly stimulated, as assayed by establishing their number, acid phosphatase activity, H2O2 production and killing ability against M tuberculosis in vitro. The in vivo model demonstrated that administration of Lentinan before infection can mobilize host defense potential and reduce mycobacterial infection. (C) 2003 Elsevier B.V. All rights reserved.
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