Journal
GENE EXPRESSION PATTERNS
Volume 3, Issue 5, Pages 579-589Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-133X(03)00118-2
Keywords
TFII-I; preimplantation; immunohistochemistry; blastocyst; transcription factor; helix-loop-helix; two-cell embryo; Williams syndrome
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Funding
- NINDS NIH HHS [NS43525] Funding Source: Medline
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BEN is a member of the TFII-I family of transcription factors, characterized by the presence of multiple helix-loop-helix repeat domains. Our immunohistochemical analysis demonstrated broad and extensive expression of BEN during mouse pre- and postimplantation development, with highest levels occuring during early to midgestation. Maternally expressed BEN is present in both the cytoplasm and nuclei of the zygote; however, it retains a predominantly nuclear localization between the two-cell stage of development and early blastocyst stages. This nuclear expression is observed in most tissues throughout development. Although, it is interesting to note that at E4.5-6.5, during early gastrulation stage, BEN is localized in the cytoplasm. At later stages, BEN retains an extensive expression pattern in a variety of developing systems implicating its involvement in tissue development and organogenesis. (C) 2003 Elsevier B.V. All rights reserved.
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