Journal
ANTIVIRAL RESEARCH
Volume 60, Issue 2, Pages 103-109Publisher
ELSEVIER
DOI: 10.1016/j.antiviral.2003.08.017
Keywords
HCV replication complex; nonstructural proteins; membranous web
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Hepatitis C virus (HCV) replicates its genome in a membrane-associated complex composed of viral proteins, replicating RNA, and altered cellular membranes. Determinants for membrane association of the HCV nonstructural proteins involved in genome replication have been defined. In addition, a specific membrane alteration, designated membranous web, was recently identified as the site of viral RNA synthesis and, therefore, represents the HCV replication complex. These findings add to our current understanding of the HCV life cycle and may ultimately allow to design novel antiviral strategies against hepatitis C. (C) 2003 Elsevier B.V. All rights reserved.
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