Journal
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
Volume 26, Issue 5, Pages 459-464Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.coc.0000037736.69148.F9
Keywords
non-small cell lung cancer; chemotherapy; recurrent disease; docetaxel
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The efficacy and toxicity of low-dose docetaxel (60 mg/m(2)) were evaluated in patients with relapsed non-small-cell lung cancer (NSCLC) after platinum-containing chemotherapy. Docetaxel 60 mg/m(2) was infused during I hour with no routine premedication, with courses repeated at 3-week intervals. Twenty-seven patients were analyzed retrospectively. The median age was 56 years (range, 32-72); 22 patients (81.5%) had adenocarcinoma, 26 (96.3%) had stage IV disease, and 23 (85.2%) were Eastern Cooperative Oncology Group performance status 0 to 1. Five patients (18.5%) had a partial response. Median progression-free survival time for all patients was 1.9 months, and median survival time was 9.4 months. The predominant toxicity was neutropenia, which was grade III or IV in 63% of patients. No neutropenic fever was observed. Other hematologic toxicities were mild (all grade 11). Thus, low-dose docetaxel (60 mg/m(2)) yielded a response rate comparable to that achieved with moderate- to high-dose docetaxel (75-100 mg/m(2)) as second-line chemotherapy in platinum-pretreated NSCLC, and had less toxicity. Further investigation of the optimal docetaxel dose as second-line chemotherapy in NSCLC is warranted.
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