4.4 Article

Synthesis and absolute configuration of (-)-3-butyl-7-hydroxyphthalide, a cytotoxic metabolite of Penicillium vulpinum

Journal

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 67, Issue 10, Pages 2240-2244

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.67.2240

Keywords

asymmetric dihydroxylation; cytotoxic compound; Penicillium vulpinum; phthalide

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Both the enantiomers as well as the racemate of 3-butyl-7-hydroxyphthalide (1) were synthesized, and the absolute configuration of the naturally occurring (-)-1 (a weakly cytotoxic metabolite of Penicillium vulpinum) was identified as S.

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