Journal
ARCHIVES OF MEDICAL RESEARCH
Volume 43, Issue 4, Pages 305-311Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.arcmed.2012.06.008
Keywords
Rectal cancer; Thrombocytosis; Prognostic factor
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Background and Aims. Thrombocytosis is frequently observed in patients with malignancy. We undertook this study to determine the prognostic value of thrombocytosis in patients with rectal cancer. Methods. We performed a retrospective study of patients undergoing low anterior resection for rectal cancer between January 2000 and March 2007. Preoperative platelet count was measured before surgery. Postoperative platelets were determined 1 month after surgery. Two-tailed p values < 0.05 were considered statistically significant. Results. One hundred sixty three patients with rectal cancer were included in the study. Preoperative platelet count > 350,000 was found in 8% of patients. Postoperative platelet count > 350,000 was found in 6% of patients. Distant metastases were found in 17 patients (10.4%). Significant variables in the multivariate analyses were preoperative platelets > 350,000 (p = 0.001), postoperative platelets > 350,000 (p = 0.002), carcinoembryonic antigen > 13 ng/dL (p = 0.003). Patients with preoperative platelet count < 350,000 showed a 5-year survival rate of 81%, whereas patients with platelet count > 350,000 had a 25-month survival [95% confidence interval (CI): 20-26]; p < 0.001. Patients with postoperative platelets < 350,000 showed a 5-year survival rate of 80%, whereas patients with platelets > 350,000 showed a 3-year survival rate of 37.5% (p < 0.05). Conclusions. Pre- or postoperative platelet count > 350,000 is associated with poor survival in patients with rectal cancer. The measurement of platelets is a clinical marker useful to define the prognosis for patients with rectal cancer. (C) 2012 IMSS. Published by Elsevier Inc.
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