4.5 Article

Incorporating prior beliefs about selection bias into the analysis of randomized trials with missing outcomes

Journal

BIOSTATISTICS
Volume 4, Issue 4, Pages 495-512

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/biostatistics/4.4.495

Keywords

Dirichlet process prior; identifiability; MCHC; non-parametric Bayes; selection model; sensitivity analysis

Funding

  1. NCI NIH HHS [CA85295, R01 CA085295-02, R01 CA085295] Funding Source: Medline
  2. NICHD NIH HHS [HD38209] Funding Source: Medline
  3. NIMH NIH HHS [MH56639] Funding Source: Medline
  4. PHS HHS [A132475] Funding Source: Medline

Ask authors/readers for more resources

In randomized studies with missing outcomes, non-identifiable assumptions are required to hold for valid data analysis. As a result, statisticians have been advocating the use of sensitivity analysis to evaluate the effect of varying asssumptions on study conclusions. While this approach may be useful in assessing the sensitivity of treatment comparisons to missing data assumptions, it may be dissatisfying to some researchers/decision makers because a single summary is not provided. In this paper, we present a fully Bayesian methodology that allows the investigator to draw a 'single' conclusion by formally incorporating prior beliefs about non-identifiable, yet interpretable, selection bias parameters. Our Bayesian model provides robustness to prior specification of the distributional form of the continuous outcomes.

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