Journal
IMMUNITY
Volume 19, Issue 4, Pages 607-620Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(03)00267-X
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Funding
- NIAID NIH HHS [AI 47231, AI 43576, 5T32 AI 07525, AI 50659] Funding Source: Medline
- NIGMS NIH HHS [2T32 GM 07367] Funding Source: Medline
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Blimp-1 is a transcriptional repressor able to drive the terminal differentiation of B cells into Ig-secreting plasma cells. We have created mice with a B cell-specific deletion of prdm1, the gene encoding Blimp-1. B cell development and the number of B cells responding to antigen appear to be normal in these mice. However, in response to either TD or TI antigen, serum Ig, short-lived plasma cells, post-GC plasma cells, and plasma cells in a memory response are virtually absent, demonstrating that Blimp-1 is required for plasmacytic differentiation and Ig secretion. In the absence of Blimp-1, CD79b(+)B220(-) pre-plasma memory B cell development is also defective, providing evidence that this subset is an intermediate in plasma cell development. B cells lacking Blimp-1 cannot secrete Ig or induce muS mRNA when stimulated ex vivo. Furthermore, although prdm1(-/-) B cells fail to induce XBP-1, XBP-1 cannot rescue plasmacytic differentiation without Blimp-1.
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