Journal
INFECTION AND IMMUNITY
Volume 71, Issue 10, Pages 6079-6082Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.71.10.6079-6082.2003
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Funding
- NIAID NIH HHS [AI 050731, AI 43474, R01 AI050731] Funding Source: Medline
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Streptococcus pyogenes protein H (sph) is an immunoglobulin-binding protein present in the Mga regulon of certain M1 serotype isolates. Although sph is present in many strains, it is frequently not expressed. In this paper we show that protein H was highly expressed after bacteria were injected into the skin of mice and were recovered from the blood, kidney, or spleen at various times postinfection. The percentage of protein H-positive colonies increased with time, reaching 100% in the spleen and kidney within 24 to 72 h postinfection. The up-regulation of sph expression was also observed in a mga mutant.
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