Journal
ARCHIVES OF INTERNAL MEDICINE
Volume 172, Issue 3, Pages 219-227Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/archinternmed.2011.683
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Funding
- National Institute of Environmental Health Sciences (NIEHS) [R21ES016829, R01ES017017]
- National Cancer Institute (NCI) [P01CA87969]
- Environmental Protection Agency (EPA) [RD832416]
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Background: Chronic exposure to particulate air pollution may accelerate cognitive decline in older adults, although data on this association are limited. Our objective was to examine long-term exposure to particulate matter (PM) air pollution, both coarse ([PM 2.5-10 mu m in diameter [PM2.5-10]) and fine (PM <2.5 mu m in diameter [PM2.5]), in relation to cognitive decline. Methods: The study population comprised the Nurses' Health Study Cognitive Cohort, which included 19 409 US women aged 70 to 81 years. We used geographic information system-based spatiotemporal smoothing models to estimate recent (1 month) and long-term (7-14 years) exposures to PM2.5-10, and PM2.5 preceding baseline cognitive testing (1995-2001) of participants residing in the contiguous United States. We used generalized estimating equation regression to estimate differences in the rate of cognitive decline across levels of PM2.5-10 and PM2.5 exposures. The main outcome measure was cognition, via validated telephone assessments, administered 3 times at approximately 2-year intervals, including tests of general cognition, verbal memory, category fluency, working memory, and attention. Results: Higher levels of long-term exposure to both PM2.5-10 and PM2.5 were associated with significantly faster cognitive decline. Two-year decline on a global score was 0.020 (95% CI, -0.032 to -0.008) standard units worse per 10 mu g/m(3) increment in PM2.5-10 exposure and 0.018 (95% CI, -0.035 to -0.002) units worse per 10 mu g/m(3) increment in PM2.5 exposure. These differences in cognitive trajectory were similar to those between women in our cohort who were approximately 2 years apart in age, indicating that the effect of a 10-mu g/m(3) increment in long-term PM exposure is cognitively equivalent to aging by approximately 2 years. Conclusion: Long-term exposure to PM2.5-10 and PM2.5 at levels typically experienced by many individuals in the United States is associated with significantly worse cognitive decline in older women.
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