Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 10, Pages 1313-1317Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np030218+
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Nine new epothilone analogues (6-8, 10, 11a, 11b, 12, 13, and 15) were isolated from fermentations of Myxococcus xanthus strains engineered with modified polyketide synthase genes. The epothilone structures were elucidated primarily through interpretation of 1D and 2D NMR data. 4-Desmethyl-10,11-didehydroepothilone D (6) displayed activity against several tumor cell lines, including a multi-drug-resistant cell line.
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