Journal
CIRCULATION JOURNAL
Volume 67, Issue 10, Pages 889-890Publisher
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.67.889
Keywords
argatroban; heparin-induced thrombocytopenia; vascular surgery
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For patients with a history of heparin-induced thrombocytopenia (HIT) who undergo cardiac or vascular surgery, the optimal anticoagulation substitute for heparin has yet to be established. Recombinant hirudin has been recommended; however, this agent is unsuitable for patients with renal dysfunction. Argatroban was used in the present patient who had a history of HIT and renal dysfunction and required peripheral vascular surgery. Argatroban was easy to monitor and control, regardless of renal function, and has advantages over other anticoagulants for such patients.
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