Journal
CELL AND TISSUE RESEARCH
Volume 314, Issue 1, Pages 61-68Publisher
SPRINGER
DOI: 10.1007/s00441-003-0749-6
Keywords
angiopoietin; Tie2 receptor; blood vessels; lymphatic vessels; VEGF; development
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This review focuses on the signaling system involving the Angiopoietin1/Tie2 receptor, which appears to be involved in the secondary stages of blood vessel formation. Although this system is crucial for blood and lymphatic vessel formation, identifying its precise role in embryonic and adult vascular biology has been a major challenge. The evidence for the key role of the Angiopoietin/Tie system is discussed, and some of the other members of the system (Ang2, Tie1) are mentioned. A comparison is made with the VEGF signaling system, which seems to provide a complementary, and somewhat more tractable, signaling system. Some of the basic unanswered questions concerning Tie/Angiopoietin biology and the secondary stages of blood vessel formation are also highlighted.
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