Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 123, Issue 1, Pages 106-109Publisher
WILEY
DOI: 10.1046/j.1365-2141.2003.04561.x
Keywords
macrophage inflammatory protein-1 alpha (MIP-1 alpha); multiple myeloma; bone disease; receptor activator of nuclear factor
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The role of serum macrophage inflammatory protein-1 alpha (MIP-1alpha) in bone disease and survival was evaluated in 85 newly diagnosed multiple myeloma ( MM) patients. MIP-1alpha was elevated in MM patients and correlated with the extent of bone disease, bone resorption markers and levels of soluble receptor activator of nuclear factor-kappaB (RANK) ligand. MIP-1alpha was also associated with survival; the 3-year probability of survival was 85% and 44% for MIP-1alpha levels below and above 48 pg/ml respectively (P = 0.021). This suggests that MIP-1alpha contributes to the pathogenesis of bone disease in MM and possibly in tumour growth, as reflected by its impact on survival.
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