Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 50, Issue 4, Pages 664-669Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.10578
Keywords
diffusion; magnetic resonance; MRI; MRS; CNS
Funding
- NCI NIH HHS [R24 CA083060, R24 CA83060] Funding Source: Medline
- NHLBI NIH HHS [R01 HL070037, R01 HL70037] Funding Source: Medline
- NINDS NIH HHS [R01 NS041519, R01 NS041519-02, R01 NS4519-01A1] Funding Source: Medline
Ask authors/readers for more resources
A general statistical model that can describe a rather large number of experimental results related to the structure of the diffusion-attenuated MR signal in biological systems is introduced. The theoretical framework relies on a phenomenological model that introduces a distribution function for tissue apparent diffusion coefficients (ADC). It is shown that at least two parameters-the position of distribution maxima (ADC) and the distribution width (sigma)-are needed to describe the MR signal in most regions of a human brain. A substantial distribution width on the order of 36% of the ADC, was found for practically all brain regions examined. This method of modeling the MR diffusion measurement allows determination of an intrinsic tissue specific ADC for a given diffusion time independent of the strength of diffusion sensitizing gradients. The model accounts for the previously found biexponential behavior of the diffusion-attenuated MR signal in CNS. (C) 2003 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available