Journal
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Volume 23, Issue 10, Pages 575-582Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/107999003322485071
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Funding
- NHLBI NIH HHS [1R01HL61577] Funding Source: Medline
- NIAID NIH HHS [1R01AI42753] Funding Source: Medline
- NIAMS NIH HHS [1KO8AR01977-01A1] Funding Source: Medline
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Leukocyte chemokine receptors (CR) are central to the pathogenesis of many human diseases, including human immunodeficiency virus-1 (HIV-1) infection. Elderly individuals infected with the HIV-1 virus have a shorter disease-free interval and worse clinic outcome. However, the reasons for this are unclear. We recently reported increased CC chemokine receptor (CCR) expression in CD4(+) T cells in aged mice, but it is not known if similar changes occur in humans. In addition, it is unclear if the observed differences are related to aged-related expansion in the memory T cell compartment. In this report, we examined the effects of aging on CCR gene expression in human peripheral blood mononuclear cells ( PBMCs), CD4(+) T cells, and naive/memory T cells. Aging is found to be associated with increased CCR1-5 expression in PBMCs and CD4(+) T cells. In addition, although the age-related increases in CCR expression occurred in both naive and memory T cells, the greatest changes were seen in the memory T cell subset. We propose that the observed aging-associated increase in T cell chemokine receptor expression may contribute to the worse clinical outcome of T cell chemokine receptor-dependent disease, such as HIV-1 infection, in the elderly.
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