Journal
AGEING RESEARCH REVIEWS
Volume 2, Issue 4, Pages 357-366Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S1568-1637(03)00026-6
Keywords
caspase; aging; apoptosis
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Caspases are a group of cysteine dependent aspartate-specific proteases. Originally found as the homolog of Ced-3 in C. elegans, 14 caspases have now been identified in mammals to date. Caspases play important roles in both the intrinsic and extrinsic apoptotic pathways and interact with the non-caspase apoptotic pathways. A number of recent published observations have suggested a strong association between apoptosis, age-related diseases and aging. Findings from our group and others reveal a strong correlation between alterations in caspase activity and aging. In this view point, we summarize current knowledge of the connection between caspases and aging observed in a variety of model systems from cultured cells in vitro to the in vivo models of rodents and humans. (C) 2003 Published by Elsevier Ireland Ltd.
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