Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 15, Issue 5, Pages 547-556Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2003.08.003
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Integrins play critical roles in development, wound healing, immunity and cancer. Central to their function is their unique ability to modulate dynamically their adhesiveness through both affinity- and valency-based mechanisms. Recent advances have shed light on the structural basis for affinity regulation and on the signaling mechanisms responsible for both affinity and valency modes of regulation.
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