Journal
NEUROSCIENCE LETTERS
Volume 349, Issue 2, Pages 136-138Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(03)00803-6
Keywords
cerebral trauma; free fatty acids; phospholipases; patient outcome
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Funding
- NINDS NIH HHS [R01-NS38905] Funding Source: Medline
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Free fatty acid (FFA) concentrations in cerebrospinal fluid (CSF) are recognized as markers of brain damage in animal studies. There is, however, relatively little information regarding FFA concentrations in human CSF in normal and pathological conditions. The present study examined FFA concentrations in CSF from 15 patients with traumatic brain injury (TBI) and compared the data with values obtained from 73 contemporary controls. Concentrations of specific FFAs from TBI patients, obtained within 48 It of the insult were significantly greater than those in the control group (arachidonic, docosahexaenoic and myristic, P < 0.001; oleic, palmitic, P < 0.01; linoleic, P < 0.05). Higher concentrations of total polyunsaturated fatty acids (P < 0.001) and of arachidonic, myristic and palmitic acids measured individually in CSF (P < 0.01) obtained I week after the insult were associated with a worse outcome at the time of hospital discharge using the Glasgow Outcome Scale. This preliminary investigation suggests that CSF FFA concentrations may be useful as a predictive marker of outcome following TBI. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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