Journal
ORGANIC LETTERS
Volume 5, Issue 20, Pages 3563-3565Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol034977v
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Funding
- NCRR NIH HHS [1 S10 RR0 8389-01] Funding Source: Medline
- NIAID NIH HHS [R01 AI043198, AI41404, AI45466] Funding Source: Medline
- NIGMS NIH HHS [T32 GM08505, GM56414] Funding Source: Medline
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The interaction between the HIV-1 Tat protein and the TAR RNA element in the nascent viral genomic transcript is required for viral replication. An 11-residue beta-peptide (1), an all-beta homologue of the Arg-rich region Tat 47-57, binds TAR RNA with K-d = 29 +/- 4 nM. A control beta-peptide (2) in which all Arg side chains are replaced by Lys side chains shows increased affinity but decreased specificity for wild-type vs bulge-deleted TAR RNA, as do the alpha-peptide analogues of 1 and 2.
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