Journal
SYNTHESIS-STUTTGART
Volume -, Issue 14, Pages 2216-2220Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2003-41045
Keywords
phosphorus; phosphinates; palladium; arylations; protecting groups
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The synthesis of a new series of arylhydroxymethylphosphinic acid derivatives is described. The protected compounds were prepared by a palladium(0) catalysed arylation of ethyl benzyloxymethylphosphinate with aryl halides. Subsequent hydrogenolysis of the benzyl protecting group followed by acidic hydrolysis of the ester function readily afforded the target compounds. Selective removal of the ester group was achieved by basic hydrolysis whereas acidic hydrolysis directly gave the totally deprotected compounds.
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