Journal
NEUROREPORT
Volume 14, Issue 14, Pages 1861-1865Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200310060-00021
Keywords
antibody expression cloning; blood-brain barrier; autoimmunity; proteomics
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Funding
- NIMH NIH HHS [MH61138] Funding Source: Medline
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An expression cloning technique was used to identify proteins selectively expressed at the blood-brain barrier that may mediate interactions between the brain microvasculature and IgG molecules. Ro52/SS-A is an IgG-binding protein and is an autoantigen implicated in Sjogren's syndrome and systemic lupus erythematosus. The present studies describe the expression cloning of this gene product from a bovine brain microvascular cDNA library. The Ro52 protein interacted with IgG molecules independent of specificity suggesting a potential role as a general antibody receptor. Northern blotting shows the Ro52/SS-A transcript is enriched in the microvascular compartment of brain. The selective expression of Ro52/SS-A in brain at the microvasculature may play a role in brain vascular involvement in autoimmune diseases.
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