Journal
FEBS LETTERS
Volume 553, Issue 1-2, Pages 151-156Publisher
WILEY
DOI: 10.1016/S0014-5793(03)01009-3
Keywords
presenilin; Herp; amyloid beta-protein; endoplasmic reticulum stress; ubiquitin-like domain; proteasome
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Herp is an endoplasmic reticulum (ER)-stress-inducible membrane protein, which has a ubiquitin-like domain (ULD). However, its biological function is as yet unknown. Previously, we reported that a high expression level of Herp in cells increases the generation of amyloid beta-protein (Abeta) and that Herp interacts with presenilin (PS). Here, we addressed the role of the ULD of Herp in Abeta generation and intracellular Herp stability. We found that the ULD is not essential for the enhancement of Abeta generation by Herp expression and the interaction of Herp with PS, but is involved in the rapid degradation of Herp, most likely via the ubiquitin/proteasome pathway. Thus, the ULD of Herp most likely plays a role in the regulation of the intracellular level of Herp under ER stress. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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