Journal
NEURON
Volume 40, Issue 2, Pages 209-227Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(03)00633-0
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01-GM68678] Funding Source: Medline
- NINDS NIH HHS [F32-NS045366] Funding Source: Medline
Ask authors/readers for more resources
Recent studies indicate the actin and microtubule cytoskeletons are a final common target of many signaling cascades that influence the developing neuron. Regulation of polymer dynamics and transport are crucial for the proper growth cone motility. This review addresses how actin filaments, microtubules, and their associated proteins play crucial roles in growth cone motility, axon outgrowth, and guidance. We present a working model for cytoskeletal regulation of directed axon outgrowth. An important goal for the future will be to understand the coordinated response of the cytoskeleton to signaling cascades induced by guidance receptor activation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available