Journal
JOURNAL OF BIOTECHNOLOGY
Volume 105, Issue 1-2, Pages 179-188Publisher
ELSEVIER
DOI: 10.1016/S0168-1656(03)00189-5
Keywords
on-line bioprocess monitoring; chemometrics; 2-D fluorescence spectroscopy; Claviceps purpurea
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Modern bioprocess control requires fast data acquisition and in-time evaluation of bioprocess variables. On-line fluorescence spectroscopy and the application of chemometric methods accomplish these goals. In order to demonstrate how time-consuming off-line analysis methods can be replaced for bioprocess monitoring, fluorescence measurements were performed during different cultivations of the fungus Claviceps purpurea. To predict process variables like biomass, protein, and alkaloid concentrations, chemometric models were developed on the basis of the acquired fluorescence spectra. The results of these investigations are presented and the applicability of this approach for bioprocess monitoring is discussed. (C) 2003 Elsevier B.V. All rights reserved.
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