Journal
BRAIN RESEARCH
Volume 987, Issue 1, Pages 25-31Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(03)03219-0
Keywords
neurofilament protein; ELISA; cerebrospinal fluid; neurodegenerative disease
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Neurofilaments, a major cytoskeletal constituent of neuronal cells, can be released into the cerebrospinal fluid during several neurodegenerative diseases. By means of a new sensitive ELISA capable of measuring 60 ng/l of neurofilament light, significant elevations were observed for different neurological disorders. Cerebral infarction presented levels of 19 800+/-9100 ng/l, amyothropic lateral sclerosis 3600+/-1200 ng/l, 'relapsing-remitting' MS 2500+/-1500 ng/l, extrapyramidal symptoms 1100+/-300 ng/l, late onset AD 300 100 ng/l and vascular dementia 1400 800 ng/l. In patients with no signs of neurological diseases the upper normal level and cut-off values was determined to be below 100 ng/l. NF-L determinations will be a valuable complement in identifying neuronal degradation and can be used clinically for diagnostic and monitoring purposes. (C) 2003 Elsevier B.V. All rights reserved.
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