Journal
STATISTICS IN MEDICINE
Volume 22, Issue 19, Pages 3089-3100Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/sim.1541
Keywords
bias; confounding; factor analysis; instrumental variables; measurement error; multiple regression
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Funding
- NIEHS NIH HHS [ES09797, ES06112] Funding Source: Medline
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Non-differential measurement error in the exposure variable is known to attenuate the dose-response relationship. The amount of attenuation introduced in a given situation is not only a function of the precision of the exposure measurement but also depends on the conditional variance of the true exposure given the other independent variables. In addition, confounder effects may also be affected by the exposure measurement error. These difficulties in statistical model development are illustrated by examples from a epidemiological study performed in the Faroe Islands to investigate the adverse health effects of prenatal mercury exposure. Copyright (C) 2003 John Wiley Sons, Ltd.
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