Journal
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Volume 18, Issue 8, Pages 847-851Publisher
WILEY
DOI: 10.1046/j.1365-2036.2003.01744.x
Keywords
-
Ask authors/readers for more resources
Background: Bacteria and viruses have been detected in the stomach of patients during acid-suppressive therapy. Aim: To investigate whether subjects using acid-suppressive drugs more often develop community-acquired respiratory infections when compared to those who do not use acid-suppressive drugs. Methods: 700 study subjects were recruited during a single week in December 2002. Information on the prevalence of clinical manifestations of infections and complications in the preceding month was assessed by questionnaire. Furthermore, subjects were asked to report antibiotic therapy and physician visits related to possible infection. Results: Questionnaires were returned by 405 subjects (58%). Consumption of acid-suppressive drugs was reported by 91 individuals, of whom 79 used proton-pump inhibitors (20%) and 12 H2-receptor antagonists (3%). Overall, 101 (25%) responders reported clinical manifestations of respiratory infection in the preceding month. Subjects using acid-suppressive drugs were 2.34 times [95% confidence interval (CI) 1.4-4.1] more likely to have clinical manifestations of infection than individuals not using acid-suppressive drugs. Subjects using acid-suppressive drugs visited a physician 3.72 times more often ( 95% CI 2.1-6.8) for an infection and received antibiotic therapy 4.19 times more often ( 95% CI 2.2-8.1) in comparison to individuals not using acid-suppressive drugs. Conclusions: Subjects using acid-suppressive drugs more often reported community-acquired respiratory infections in comparison to those who did not use acid-suppressive drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available