Journal
CARDIOVASCULAR RESEARCH
Volume 60, Issue 1, Pages 5-10Publisher
OXFORD UNIV PRESS
DOI: 10.1016/S0008-6363(03)00437-1
Keywords
myocarditis; dilated cardiomyopathy; Autoimmunity; heart failure; immunosuppression
Categories
Ask authors/readers for more resources
Myocarditis is a complex disease because multiple pathogenetic mechanisms play a role. While these mechanisms appear to act in a chronological cascade, they undoubtedly overlap in some cases, rendering diagnosis and treatment difficult. Ultimately, dilated cardiomyopathy (DCM) may result. A multitude of still-circumstantial evidence points to a major role of viral myocarditis in the etiology of DCM. The common presence of viral genetic material and viral proteins in the myocardium of patients with DCM provides the most compelling evidence, but proof of causality is still lacking. Nevertheless, because of the striking increase in heart failure prevalence in recent years, anti-viral and anti-inflammatory therapies should be developed for their potential to prevent or ameliorate DCM. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available