Journal
ONCOGENE
Volume 22, Issue 46, Pages 7209-7217Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1206804
Keywords
E2F; Rb; biological pathways
Funding
- NCI NIH HHS [CA 85839] Funding Source: Medline
Ask authors/readers for more resources
The E2F family of transcription factors are critical regulators of the cell cycle and have also been implicated in apoptosis, development, DNA damage checkpoints, and differentiation. Retinoblastoma (Rb) proteins interact with E2F to regulate transcription, and several mechanisms have been proposed for Rb-E2F transcriptional regulation. We designed microarray-based experiments to characterize the relative contributions of each mechanism, and unexpectedly, we found that distinct functional gene groups show preference for one mechanism over the others. We propose that such a distribution may provide signaling specificity to enable regulatory proteins to turn on or off entire pathways that determine cell fate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available