4.7 Article

Use of sonication for the coupling of sterically hindered substrates in the phenolic Mitsunobu reaction

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 68, Issue 21, Pages 8261-8263

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo0345751

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A vast rate increase in the Mitsunobu reaction of phenols with alcohols where either or both are sterically hindered has been achieved by the use of high concentration combined with sonication.

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