4.7 Article

Asymmetric synthesis of the quinolizidine alkaloid (-)-epimyrtine with intramolecular Mannich Cyclization and n-sulfinyl δ-amino β-ketoesters

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 68, Issue 21, Pages 8061-8064

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo030208d

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Funding

  1. NIGMS NIH HHS [GM 51982] Funding Source: Medline

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A concise, six-step, enantioselective synthesis of (-)-epimyrtine employing the N-sulfinyl delta-amino beta-ketoester chiral building block is described.

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