The first enantiospecific synthesis of (-)-koumidine via the intramolecular palladium-catalyzed enolate driven cross coupling reaction.: The stereospecific introduction of the 19-(Z) ethylidene side chain

The stereospecific synthesis of (-)-koumidine wits realized by replacement of triphenylphosphine with tricyclohexylphosphine in the enolate driven palladium-catalyzed cross coupling process. (C) 2003 Elsevier Ltd. All rights reserved.