Journal
FEBS LETTERS
Volume 553, Issue 3, Pages 304-308Publisher
WILEY
DOI: 10.1016/S0014-5793(03)01034-2
Keywords
hepatitis B virus X protein; nuclear factor kappa B; interferon alpha
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X gene product of hepatitis B virus (HBV) (HBx) regulates many transcription factors including nuclear factor kappa B (NF-kappaB) and plays a key role in hepatocarcinogenesis. In this study, we demonstrated that the expression of full HBV genome and HBx gene similarly stimulated the transcriptional activity of NF-kappaB in HuH-7 human hepatoma cells, and that interferon (IFN)-alpha as well as dominant negative mutant of IkappaB kinase-a effectively inhibited the HBx-mediated NF-kappaB activation, but IFN-gamma did not. These results suggest that IFN-alpha may have a function to block the NF-kappaB activating pathway triggered by HBx in HBV hepatocytes. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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