Journal
FEBS LETTERS
Volume 553, Issue 3, Pages 403-407Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(03)01072-X
Keywords
tumor necrosis factor receptor-associated factor 3; tumor necrosis factor receptor; jun N-terminal kinase; nuclear factor kappa B; subcellular localization; signal transduction
Funding
- NCI NIH HHS [5-T32-CA009120-26, R01 CA87924] Funding Source: Medline
- NIGMS NIH HHS [GM55052, GM08042, GM57559] Funding Source: Medline
Ask authors/readers for more resources
Previous studies suggest that localization of tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family members is important for regulating their signal transduction. During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we identified a novel protein, T3JAM (TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator). This protein associates specifically with TRAF3 but not other TRAF family members. Coexpression of T3JAM with TRAF3 recruits TRAF3 to the detergent-insoluble fraction. More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-kappaB. Our studies indicate that T3JAM may function as an adapter molecule that specifically regulates TRAF3-mediated JNK activation. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available