Journal
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
Volume 290, Issue 3, Pages 533-541Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00404-014-3219-3
Keywords
MicroRNA-543; Endometrial cancer; FAK; TWIST1
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Funding
- Natural Scientific Research Fund of China [81100916]
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Focal adhesion kinase (FAK) is a critical mediator of extracellular matrix signaling, cell survival, proliferation and motility. Twist homolog 1 (TWIST1) is a transcription factor and serves as a powerful oncogene. Increased FAK and TWIST1 expression are observed in a variety of solid human tumors and correlate with metastasis and poor survival. Here, we identify miR-543 as a direct regulator of FAK and TWIST1 expression in endometrial cancer. Forced expression of miR-543 in endometrial cancer cell lines decreases both endogenous FAK and TWIST1 mRNA and protein levels. Forced expression of miR-543 in aggressive endometrial cancer cell lines also impairs tumor cell monolayer proliferation, anchorage-independent growth, migration and invasion. Endogenous miR-543 expression is decreased in malignant versus normal endometrium tissue and the levels of miR-543 inversely correlate with mRNA levels of FAK and TWIST1. miR-543 expression is decreased in endometrial cancer and serves as a tumor suppressor by targeting FAK and TWIST1 expression.
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