Journal
CANCER LETTERS
Volume 200, Issue 2, Pages 153-160Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(03)00415-4
Keywords
c-ski; skeletal muscle hypertrophy; protein turnover; ubiquitin-dependent proteolytic pathway
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We have investigated the protein turnover modulations involved in the hypertrophic muscle phenotype of c-ski overexpressing transgenic mice. In these animals, the body weight is increased and all the muscles examined show a definite hypertrophy. The protein degradation rate is significantly reduced in the fast twitch muscles of c-ski transgenic animals with respect to controls; in contrast, there are no detectable differences in the synthesis rates. The down-regulation of protein breakdown is paralleled by decreased expression of genes belonging to the lysosomal as well as to the ATP-ubiquitin-dependent proteolytic pathways. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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