Journal
ORGANIC LETTERS
Volume 5, Issue 22, Pages 4227-4230Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol035746r
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Cyclic amines may be prepared via a sequence of deprotection followed by intramolecular reductive amination of t-Boc-protected amino ketones under asymmetric transfer hydrogenation conditions. In cases where the corresponding imine reaction proceeds with high enantioselectivity, this is reflected in the one-step process.
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