Journal
JOURNAL OF CONTROLLED RELEASE
Volume 92, Issue 3, Pages 361-368Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-3659(03)00363-8
Keywords
controlled release; coating layer; permeable particles; mathematical model; random walk simulation
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An enhanced method was proposed for controlled release of core material using a coating layer of fine permeable particles dispersed in an impermeable wax prepared by dry-based process. A mathematical model was constructed to describe in detail the core material release by diffusion through the connected permeable particles inside the coating layer. The effective diffusivity was simulated by a random walk method taking into account the structure of the coating layer. The released characteristics were measured for the urea core particle coated with the layer of the starch permeable particles dispersed in the paraffin wax. The calculated results were in a good quantitative agreement with experimental data in all range of coating conditions. As a result, the low release rate was proven to be obtained with thicker coating layer of lower volume fraction of permeable particles. Moreover, the application of permeable particles instead of soluble ones [J. Chem. Eng. Jpn. 35 (2002) 40] resulted in significant decrease in release rate. (C) 2003 Elsevier B.V. All rights reaserved.
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