Journal
NEURON
Volume 40, Issue 3, Pages 457-460Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(03)00681-0
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Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data from human patients provide converging evidence that aberrant tau phosphorylation can cause a neurodegenerative phenotype similar to that seen in human neurodegenerative diseases.
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