Journal
BRAIN RESEARCH
Volume 989, Issue 1, Pages 117-121Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(03)03367-5
Keywords
lipopolysaccharide stress; catecholamine; thyrosine hydroxylase immunoreactivity; dopamine-beta-hydroxylase immunoreactivity; 6-hydroxy-dopamine treatment
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Central stress regulatory pathways utilize various neurotransmitters/neuropeptides, such as urocortin (Ucn) and catecholamines. Ucn is most abundantly expressed in the Edinger-Westphal nucleus (E-WN), co-distributed with catecholaminergic terminals. Acute stress recruits E-WN neurons, and ascending catecholaminergic pathways also contribute to the activation of various brain areas in response to stress. We hypothesized that catecholamine and Ucn interactions in the E-WN mediated the recruitment of these neurons in response to stress. Using double-labeling immunohistochemistry, we found close appositions between urocortin-immunoreactive nervous structures and dopaminergic terminals. however, depletion of them had no effect on the activation pattern of E-WN neurons upon acute immune challenge. From these results we conclude that dopaminergic terminals innervating E-WN Ucn neurons do not play a major role in mediating the responses of E-WN neurons upon acute immune challenge. (C) 2003 Elsevier B.V. All rights reserved.
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