Journal
MOLECULAR IMMUNOLOGY
Volume 40, Issue 7, Pages 395-405Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0161-5890(03)00152-4
Keywords
lactoferrin; lactoferricin; cationic peptides; antimicrobials; iron
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Lactoferrin is a member of the transferrin family of iron-binding proteins. Numerous functions have been reported and continue to be reported for the protein, some of which are related to its iron-binding properties. Its extensive antimicrobial activities were originally attributed to its ability to sequester essential iron, however, it is now established that it possesses bactericidal activities as a result of a direct interaction between the protein or lactoferrin-derived peptides. This article reviews the antimicrobial activities of lactoferrin and discusses the potential mode of action of lactoferrin-derived cationic peptides against Gram-negative bacteria in the light of recent studies. (C) 2003 Elsevier Ltd. All rights reserved.
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