Journal
NATURE GENETICS
Volume 35, Issue 3, Pages 215-217Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng1253
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To address the biological function of RNA interference (RNAi) related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1 - null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1 - null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.
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