Journal
MECHANISMS OF DEVELOPMENT
Volume 120, Issue 11, Pages 1327-1336Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2003.05.002
Keywords
extracellular matrix; endochondral ossification; chondrocyte; osteoblast
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Funding
- NIAMS NIH HHS [R01 AR046238-08, AR46238, R01 AR046238] Funding Source: Medline
- NIA NIH HHS [AG23218, R01 AG023218-02, R01 AG023218] Funding Source: Medline
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The extracellular matrix (ECM), once thought to be a static structural component of tissues, is now known to play a complex and dynamic role in a variety of cellular functions in a number of diverse tissues. A significant body of literature attests to the ability of the ECM to communicate both spatial and temporal information to adherent cells, thereby directing cell behavior via interactions between the ECM and cell-surface receptors. Moreover, volumes of experimental data show that a great deal of communication travels in the opposite direction, from the cell to the ECM, allowing for regulation of the cues transmitted by the ECM. As such, the ECM, with respect to its components and their organization, is not a fixed reflection of the state the local microenvironment in which a cell finds itself at a particular time, but rather is able to respond to and effect changes in its local microenvironment. As an example of the developmental consequences of ECM interactions, this review gives an overview of the 'give and take' relationship between the ECM and the cells of the developing skeletal elements, in particular, the chondrocyte. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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