Journal
PANCREAS
Volume 27, Issue 4, Pages E84-E89Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00006676-200311000-00019
Keywords
somatostatin; somatostatin receptor; islet physiology
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Funding
- NIDDK NIH HHS [DK 46441-02] Funding Source: Medline
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Objectives: Five distinct somatostatin receptors (SSTRs) have been cloned, characterized, and designated SSTRs 1 - 5. The role of these receptors in B-cell signaling has not been well characterized. Methods: In the current study, the isolated perfused human pancreas model was used to determine the specific effect of 4 different somatostatin receptor agonists on insulin secretion. Conclusion: We demonstrated that the SSTR 2 agonist and octreotide significantly suppressed insulin secretion. Furthermore, even during the immunoneutralization of endogenous intrapancreatic somatostatin, the SSTR 2 agonist was able to reverse the effect of somatostatin immunoneutralization by suppressing insulin secretion. These results demonstrate that activation of SSTR 2 suppresses insulin secretion in the isolated perfused human pancreas.
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