An efficient synthesis of α-aryl β-(N-tosyl)amino phosphonate derivatives from α-diazophosphonate

The alpha-diazophosphonate was added to aryl (N-tosyl)imine to give beta-aryl beta-(N-tosyl)amino alpha-diazophosphonates, which were further subjected to TsOH-catalyzed diazo decomposition to yield alpha-aryl beta-(N-tosyl)enaminophosphonates through 1,2 aryl migration. The alpha-aryl beta-(N-tosyl)enamino phosphonates were hydrogenated to give alpha-aryl beta-(N-tosyl)amino phosphonates. (C) 2003 Elsevier Ltd. All rights reserved.