Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 46, Issue 23, Pages 4904-4909Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm030417q
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Dimers of vancomycin (Van), linked by a rigid metal complex, [Pt(en)(H2O)(2)](2+), exhibit potent activities (MIC similar to0.8 mug/mL, similar to720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.
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