Journal
SCIENCE
Volume 302, Issue 5647, Pages 1053-1056Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1089525
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Funding
- NCI NIH HHS [P01CA27489] Funding Source: Medline
- NIAID NIH HHS [5T32AI07606] Funding Source: Medline
- NIGMS NIH HHS [GM 43858] Funding Source: Medline
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Here, we report evidence for the production of ozone in human disease. Signature products unique to cholesterol ozonolysis are present within atherosclerotic tissue at the time of carotid endarterectomy, suggesting that ozone production occurred during lesion development. Furthermore, advanced atherosclerotic plaques generate ozone when the leukocytes within the diseased arteries are activated in vitro. The steroids produced by cholesterol ozonolysis cause effects that are thought to be critical to the pathogenesis of atherosclerosis, including cytotoxicity, lipid-loading in macrophages, and deformation of the apolipoprotein B-100 secondary structure. We propose the trivial designation atheronals for this previously unrecognized class of steroids.
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