Journal
SCIENCE
Volume 302, Issue 5647, Pages 1041-1043Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1090148
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- NIAID NIH HHS [AI-042370] Funding Source: Medline
- NIGMS NIH HHS [GM-07229] Funding Source: Medline
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Activated CD8(+) T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8(+) T cells. We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8(+) T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8(+) T cells, including interferon-gamma (IFN-gamma), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8(+) T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.
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